hrp0095p1-145 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

Spatial navigation and memory in transgender male adolescents treated with gender affirming hormones

Perl Liat , Oren Asaf , C. Mueller Sven , Raphael Ido , Borger Ophir , Sheppes Tamar , Shechner Tomer

Background: Spatial navigation is an essential human skill that helps individuals track their changes in position and orientation by integrating self-motion cues. Meta-analyses indicate that males, on average, perform better than females on a number of spatial tasks. Sex steroids, mainly androgens, modulate the remodeling of synapses in the prefrontal cortex and hippocampus, a limbic brain area with critical influence on spatial and contextual memory. Androgen...

hrp0094p2-201 | Fat, metabolism and obesity | ESPE2021

Weight status and body composition of children and adolescents during the COVID-19 pandemic

Brener Avivit , Azoulay Erez , Yackobovitch-Gavan Michal , Lopez Adar , Sheppes Tamar , Yaacov Hadar , Gilboa Inbar , Waksman Yarden , Lebenthal Yael ,

Background: The COVID-19 pandemic has tremendous effects on lifestyle that could potentially cause health-related problems. Therefore, extreme preventive measures were taken, including the closure of schools and after school activities. This dramatic alteration in daily routine could lead to adverse consequence of increasing obesity. In this study we aimed to investigate the change in weight status and body composition parameters of children and adolescents du...

hrp0095p1-368 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2022

Gender dimorphism in transgender youth – hormonal therapy and the balance between muscle, adipose tissue and cardiometabolic alterations

Borger Ophir , Oren Asaf , Perl Liat , Yackobovitch-Gavan Michal , Sheppes Tamar , Brener Avivit , Elkon-Tamir Erella , Israeli Galit , Segev-Becker Anat , Lebenthal Ophir Yael

Context: Given the importance of sex hormones in metabolic regulation, dynamics in body composition and cardiometabolic alterations may occur in transgender persons receiving gender-affirming hormone (GAH) therapy.Objectives: Our aim was to explore the association between muscle-to-fat ratio (MFR) and the risk for metabolic syndrome components in transgender youth.Methods: In 71 tr...